The NOD and C3H-IL10 knockout mice
from Massachusetts Biotechnology Council
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Thursday, September 18, 2008, 8:00am - 10:00am
The NOD mouse model of autoimmune Type 1 diabetes and the C3H-IL10 knockout mouse model of colitis: two complex disease models characterized by defects in innate immunity but with opposite effects of microbial challenge on disease development.
Mouse models of complex diseases in humans typically entail an interaction between a susceptible genotype and an environmental factor(s). Microbial factors are commonly implicated in inflammatory diseases. The NOD/LtJ mouse is an excellent polygenic model for autoimmune, T cell-mediated Type 1 diabetes in humans. To achieve a high penetrance of the diabetes susceptibility genes (e.g., high diabetes incidence), NOD mice must be maintained at high barrier status; exposure of young mice to either bacterial or viral reagents suppresses diabetes development.
Presenter
Edward H. Leiter, Senior Staff Scientist, The Jackson Laboratory, Bar Harbor, ME
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